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Article

Evaluation of the Genetic Basis of Familial Aggregation of Pacemaker Implantation by a Large Next Generation Sequencing Panel.

PloS one - 1 Jan 2015

Celestino-Soper Patrícia B S, Doytchinova Anisiia, Steiner Hillel A, Uradu Andrea, Lynnes Ty C, Groh William J, Miller John M, Lin Hai, Gao Hongyu, Wang Zhiping, Liu Yunlong, Chen Peng-Sheng, Vatta Matteo

Abstract excerpt

BACKGROUND: The etiology of conduction disturbances necessitating permanent pacemaker (PPM) implantation is often unknown, although familial aggregation of PPM (faPPM) suggests a possible genetic basis. We developed a pan-cardiovascular next generation sequencing (NGS) panel to genetically characterize a selected cohort of faPPM. MATERIALS AND METHODS: We designed and validated a custom NGS panel targeting the...

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Source

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Identifiers

PMID: 26636822
DOI: 10.1371/journal.pone.0143588
PMCID: PMC4670209

Genes

TRPM4
ABCC9
APOB
LDB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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