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Article

Identification of Potential Immune Checkpoint Inhibitor Targets in Gliomas via Bioinformatic Analyses.

BioMed research international - 1 Jan 2022

Ding Mengmeng, Li Yong-An, Lu Zhimin, Hou Guoxin

Abstract excerpt

BACKGROUND: Glioma is a common tumor originating from the glial cells of the brain. Immune checkpoint inhibitors can potentially be used to treat gliomas, although no drug is currently approved. METHODS: The expression levels of the immune checkpoint genes in glioma and normal tissues, and their correlation with the IDH mutation status and complete 1p/19q codeletion, were analyzed using The Cancer Genome Atlas...

Topics

Brain Neoplasms
Computational Biology
Databases, Genetic
Glioma
Hepatitis A Virus Cellular Receptor 2
Humans
Immune Checkpoint Inhibitors
Mutation
Protein Interaction Maps
Survival Analysis

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Identifiers

PMID: 35198632
DOI: 10.1155/2022/1734847
PMCID: PMC8860561

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