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Article

Evaluation of alternative methods for estimating the precision of REML-based estimates of variance components and heritability.

Heredity - 1 Apr 2022

Rameez Roshan, Jahageerdar Shrinivas, Jayaraman Jayasankar, Chanu Thongam Ibemcha, Bangera Rama, Gilmour Arthur

Abstract excerpt

Residual Maximum Likelihood (REML) analysis is the most widely used method to estimate variance components and heritability. This method is based on large sample theory under the assumption that the parameter estimates are asymptotically multivariate normally distributed with covariance matrix given by the inverse of the information matrix. Hence, these sampling variances could be biased if the assumption of...

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PMID: 35197554
DOI: 10.1038/s41437-022-00509-1
PMCID: PMC8986777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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