Article
A robust DF-REML framework for variance components estimation in genetic studies.
Bioinformatics (Oxford, England) - 15 Nov 2017
Lourenço V M, Rodrigues P C, Pires A M, Piepho H-P
Abstract excerpt
MOTIVATION: In genetic association studies, linear mixed models (LMMs) are used to test for associations between phenotypes and candidate single nucleotide polymorphisms (SNPs). These same models are also used to estimate heritability, which is central not only to evolutionary biology but also to the prediction of the response to selection in plant and animal breeding, as well as the prediction of disease risk in...
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