Article
Dependence of blood biochemical parameters on various genotypes of the UGT1A1 gene associated with gilbert's syndrome.
Klinicheskaia laboratornaia diagnostika - 23 Feb 2022
Sidorenko Dar'ja Vladimirovna, Nazarov V D, Volnikova E G, Kondrasheva E A, Peshkova N G, Kovaleva I S, Kokorina O S, Svatkovskaya I B, Lapin S V
Abstract excerpt
Diagnosis of Gilbert's syndrome is based on the detection of homozygous carriage of an additional TA-repeat in the promoter of the UGT1A1 gene, leading to a decrease in the activity of the UGT enzyme. No large studies have been done in the Russian Federation on the prevalence of carriage of Gilbert's syndrome, as well as the biochemical and molecular profile of such patients. The aim of the study is to evaluate...
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