Article
Alterations in the immune phenotype of thymectomized children and the development of atopic disorders after heart transplantation.
Pediatric transplantation - 1 Jun 2022
Kim Tiffany B, Ionescu Lavinia, Avdimiretz Nicholas, Murdoch Faye, Larsen Ingrid M, Motyka Bruce, West Lori J, Urschel Simon
Abstract excerpt
BACKGROUND: Atopic disorders are more common in children after heart transplant (HTx). We hypothesized that HTx at an early age and thymus excision (TE) affect development of T and B cells, especially regulatory T cells (Tregs), which help maintain tolerance. METHODS: In this single-center study including 24 patients transplanted between 2013 and 2018, we investigated lymphocyte patterns in relation to these...
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