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Article

Effect of hepar-protecting Wuzhi capsule on pharmacokinetics and dose-effect character of tacrolimus in healthy volunteers.

Biopharmaceutics & drug disposition - 1 Aug 2022

Teng Fei, Wang Wei, Zhang Weiyue, Qu Jinlong, Liu Binguo, Chen Jiani, Liu Shiyi, Li Mingming, Chen Wansheng, Wei Hua

Abstract excerpt

Wuzhi capsule (WZC), a preparation of Fructus Schisandra sphenanthera extract, has been used widely for the treatment of viral and drug-induced hepatitis in China. This study aimed to determine the pharmacokinetic parameters of tacrolimus (TAC) when co-administered with WZC and the dose-effect of WZC on tacrolimus in healthy volunteers. The effect of an increased dosage of WZC (1, 2, 6, and 8 capsules once daily)...

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Identifiers

PMID: 35180322
DOI: 10.1002/bdd.2312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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