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Article

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.

Cell reports - 15 Feb 2022

Przanowska Roza K, Weidmann Chase A, Saha Shekhar, Cichewicz Magdalena A, Jensen Kate N, Przanowski Piotr, Irving Patrick S, Janes Kevin A, Guertin Michael J, Weeks Kevin M, Dutta Anindya

Abstract excerpt

Many lncRNAs have been discovered using transcriptomic data; however, it is unclear what fraction of lncRNAs is functional and what structural properties affect their phenotype. MUNC lncRNA (also known as DRReRNA) acts as an enhancer RNA for the Myod1 gene in cis and stimulates the expression of other promyogenic genes in trans by recruiting the cohesin complex. Here, experimental probing of the RNA structure...

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Identifiers

PMID: 35172143
DOI: 10.1016/j.celrep.2022.110361
PMCID: PMC8937029

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