Article
Combining structure-based and 3D QSAR pharmacophore models to discover diverse ligands against EGFR in oral cancer.
Future medicinal chemistry - 1 Apr 2022
Chakraborty Purbali, Ahil Sajeli Begum, Jamma Trinath, Yogeeswari Perumal
Abstract excerpt
Background: Epidermal growth factor receptor-tyrosine kinase (EGFR-TK) is a well-known hallmark of oral and oropharyngeal cancers, as its overexpression leads to poor prognosis and malignancy. The activating EGFR mutations (particularly T790M and L858R double mutant) are a major challenge causing drug resistance, especially in the treatment of oral cancers. Methodology: This paper is an effort to exploit both...
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