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Article

Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.

International journal of molecular sciences - 30 Jan 2022

Gogna Navdeep, Weatherly Sonia, Zhao Fuxin, Collin Gayle B, Pinkney Jai, Stone Lisa, Naggert Jürgen K, Carter Gregory W, Nishina Patsy M

Abstract excerpt

Adipor1tm1Dgen and Mfrprd6 mutant mice share similar eye disease characteristics. Previously, studies established a functional relationship of ADIPOR1 and MFRP proteins in maintaining retinal lipidome homeostasis and visual function. However, the independent and/or interactive contribution of both genes to similar disease phenotypes, including fundus spots, decreased axial length, and photoreceptor degeneration...

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Identifiers

PMID: 35163536
DOI: 10.3390/ijms23031615
PMCID: PMC8835889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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