Article
Role of the mtDNA Mutations and Mitophagy in Inflammaging.
International journal of molecular sciences - 25 Jan 2022
Dabravolski Siarhei A, Nikiforov Nikita G, Zhuravlev Alexander D, Orekhov Nikolay A, Grechko Andrey V, Orekhov Alexander N
Abstract excerpt
Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial...
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