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Article

Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.

Microbiology spectrum - 23 Feb 2022

Song Jing, Du Weili, Liu Zichen, Che Jialu, Li Kun, Che Nanying

Abstract excerpt

Next-generation sequencing (NGS) enables rapid identification of common and rare drug-resistant genetic variations from tuberculosis (TB) patients' sputum samples and MTB isolates. However, whether this technology is effective for formalin-fixed and paraffin-embedded (FFPE) tissues remains unclear. An amplicon-based targeted NGS sequencing panel was developed to predict susceptibility to 9 antituberculosis drugs,...

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Identifiers

PMID: 35138166
DOI: 10.1128/spectrum.01358-21
PMCID: PMC8826733

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