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Article

Quantifying the DNA-damaging Effects of FLASH Irradiation With Plasmid DNA

3 Feb 2022

Abstract excerpt

Purpose To investigate a plasmid DNA nicking assay approach for isolating and quantifying the DNA-damaging effects of ultrahigh-dose-rate (ie, FLASH) irradiation relative to conventional dose-rate irradiation. Methods and Materials We constructed and irradiated phantoms containing plasmid DNA to nominal doses of 20 Gy and 30 Gy using 16 MeV electrons at conventional (0.167 Gy/s) and FLASH (46.6 Gy/s and 93.2...

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PMID: 35124135
DOI: 10.1016/j.ijrobp.2022.01.049

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