Efficacy and safety of olaparib according to age in BRCA1/2-mutated patients with recurrent platinum-sensitive ovarian cancer: Analysis of the phase III SOLO2/ENGOT-Ov21 study.

doi:10.1016/j.ygyno.2022.01.024

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Efficacy and safety of olaparib according to age in BRCA1/2-mutated patients with recurrent platinum-sensitive ovarian cancer: Analysis of the phase III SOLO2/ENGOT-Ov21 study.

Gynecologic oncology - 1 Apr 2022

Trillsch Fabian, Mahner Sven, Ataseven Beyhan, Asher Rebecca, Aryal Nanda, Dubot Coraline, Clamp Andrew, Penson Richard T, Oza Amit, Amit Amnon, Huzarski Tomasz, Casado Antonio, Scambia Giovanni, Friedlander Michael, Colombo Nicoletta, Fujiwara Keiichi, Sonke Gabe S, Denys Hannelore, Lowe Elizabeth S, Lee Chee K, Pujade-Lauraine Eric

Abstract excerpt

BACKGROUND: Olaparib has significantly improved outcome and patient-centered endpoints in BRCA1/2-mutated patients with recurrent platinum-sensitive ovarian cancer (PSOC). Specific information on efficacy and safety of olaparib for older patients appears of special interest. METHODS: 295 patients from the SOLO2 trial randomly assigned to olaparib or placebo were categorized according to age-cutoff at 65 years....

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PMID: 35115180
DOI: 10.1016/j.ygyno.2022.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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