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Article

β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity.

Scientific reports - 2 Feb 2022

Denha Sarah A, Atang Alexandra E, Hays Thomas S, Avery Adam W

Abstract excerpt

Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem calponin homology domains (CH1 and CH2). Here we investigated in Drosophila the significance of the β-spectrin N-terminus, and explored its functional interaction...

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Identifiers

PMID: 35110634
DOI: 10.1038/s41598-022-05762-2
PMCID: PMC8810934

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