Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reproductive and developmental toxicities of 5-fluorouracil in model organisms and humans

1 Jan 2022

Abstract excerpt

Chemotherapy, as an important clinical treatment, has greatly enhanced survival in cancer patients, but the side effects and long-term sequelae bother both patients and clinicians. 5-Fluorouracil (5-FU) has been widely used as a chemotherapeutic agent in the clinical treatment of various cancers, but several studies showed its adverse effects on reproduction. Reproductive toxicity of 5-FU often associates with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Risks and Factors
Share to Renal and related cancers
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35098910
DOI: 10.1017/erm.2022.3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reproductive and developmental toxicities of 5-fluorouracil in model organisms and humansPMID 35098910Read ↗

The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivoSemantic proximity Read ↗

Gonadotoxicity of immunotherapy and targeted agents in patients with cancer and impact on subsequent pregnanciesSemantic proximity Read ↗

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of hydroxyureaSemantic proximity Read ↗

Critical windows of exposure for children's health: the reproductive system in animals and humans.Semantic proximity Read ↗

The research progress on the impact of antibiotics on the male reproductive systemSemantic proximity Read ↗

Anticancer drug 5-fluorouracil induces reproductive and developmental defects in Caenorhabditis elegansSemantic proximity Read ↗

Novel insights into the pathophysiology of chemotherapy-induced damage to the ovarySemantic proximity Read ↗

The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agentsSemantic proximity Read ↗

Life cycle exposure to 2-phenylbenzimidazole-5-sulfonic acid disrupts reproductive endocrine system and induces transgenerational adverse effects in zebrafishSemantic proximity Read ↗

Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosisSemantic proximity Read ↗

Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro†Semantic proximity Read ↗

Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3RsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.