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Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants.

Medical microbiology and immunology - 1 Feb 2022

Dächert Christopher, Muenchhoff Maximilian, Graf Alexander, Autenrieth Hanna, Bender Sabine, Mairhofer Helga, Wratil Paul R, Thieme Susanne, Krebs Stefan, Grzimek-Koschewa Natascha, Blum Helmut, Keppler Oliver T

Abstract excerpt

On November 26, 2021, the World Health Organization classified B.1.1.529 as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VoC), named omicron. Spike-gene dropouts in conventional SARS-CoV-2 PCR systems have been reported over the last weeks as indirect diagnostic evidence for the identification of omicron. Here, we report the combination of PCRs specific for heavily mutated...

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Identifiers

PMID: 35061086
DOI: 10.1007/s00430-022-00728-7
PMCID: PMC8780046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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