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Complete genome sequencing and evolutionary analysis of hepatitis C virus subtype 6a, including strains from Guangdong Province, China.

Archives of virology - 1 Feb 2022

Xu Ru, Wang Hao, Huang Jieting, Wang Min, Liao Qiao, Shan Zhengang, Zhong Huishan, Rong Xia, Fu Yongshui

Abstract excerpt

We performed an evolutionary analysis using whole genome sequence isolates of hepatitis C virus (HCV) 6a from Guangdong Province and reference sequences from various countries. Less than 5% of the HCV genome was found to be under positive selection. The E1 and E2 proteins had the highest proportion of positively selected sites both within and outside of CD8 T cell epitopes in all of the strains. Regions...

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Identifiers

PMID: 35050401
DOI: 10.1007/s00705-021-05358-7
PMCID: PMC8771652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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