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Article

CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3

18 Jan 2022

Abstract excerpt

Abstract Background Functions of CircMET (hsa_circ_0082002) which is a circular RNA and derived from MET gene remain understood incompletely. In the present study, Xp11.2 translocation/ NONO-TFE3 fusion renal cell carcinoma ( NONO-TFE3 tRCC) with up-regulated CircMET was employed to investigate its mechanism in cancer progression and post-transcriptional regulation. Methods FISH and real-time PCR were performed...

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PMID: 35042525
DOI: 10.1186/s12943-022-01497-w

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