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Article

Canonical Thyroid Hormone Receptor β Action Stimulates Hepatocyte Proliferation in Male Mice.

Endocrinology - 1 Mar 2022

Hönes Georg Sebastian, Kerp Helena, Hoppe Christoph, Kowalczyk Manuela, Zwanziger Denise, Baba Hideo Andreas, Führer Dagmar, Moeller Lars Christian

Abstract excerpt

CONTEXT: 3,5,3'-L-triiodothyronine (T3) is a potent inducer of hepatocyte proliferation via the Wnt/β-catenin signaling pathway. Previous studies suggested the involvement of rapid noncanonical thyroid hormone receptor (TR) β signaling, directly activating hepatic Wnt/β-catenin signaling independent from TRβ DNA binding. However, the mechanism by which T3 increases Wnt/β-catenin signaling in hepatocytes has not...

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PMID: 35038735
DOI: 10.1210/endocr/bqac003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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