Article
Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments.
Molecular therapy : the journal of the American Society of Gene Therapy - 2 Mar 2022
Yang Chen, Wu Siqi, Mou Zezhong, Zhou Quan, Dai Xiyu, Ou Yuxi, Chen Xinan, Chen Yiling, Xu Chenyang, Hu Yun, Zhang Limin, Zou Lujia, Jin Shengming, Hu Jimeng, Mao Shanhua, Jiang Haowen
Abstract excerpt
Circular RNAs (circRNAs) play critical roles in different diseases. Exosomes are important intermediates of intercellular communication. While both have been widely reported in cancers, exosome-derived circRNAs are rarely studied. In this work, we identified the differently expressed circRNAs in bladder cancer (BCa) tissue and exosomes through high-throughput sequencing. RNA pull-down, RNA immunoprecipitation,...
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