Article
High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis.
Cell death & disease - 20 Jul 2021
Yang Chen, Mou Zezhong, Wu Siqi, Ou Yuxi, Zhang Zheyu, Chen Xinan, Dai Xiyu, Xu Chenyang, Mao Shanhua, Jiang Haowen
Abstract excerpt
Bladder cancer (BC) is known as a common and lethal urinary malignancy worldwide. Circular RNAs (circRNAs), an emerging non-coding RNA, participate in carcinogenesis process of several cancers including BC. In this study, high-throughput sequencing and RT-qPCR were applied to discover and validate abnormal high expression of circUBE2K in BC tissues. Fluorescence in situ hybridization (FISH) was used to detect...
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