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Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

Neurobiology of disease - 1 Mar 2022

Heighway Jacqueline, Sedo Alicia, Garg Anjali, Eldershaw Lauren, Perreau Victoria, Berecki Géza, Reid Christopher A, Petrou Steven, Maljevic Snezana

Abstract excerpt

Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A, and SCN8A. Gene expression is developmentally regulated, and they are known to express functionally distinct transcript variants. Precision therapies targeting these...

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PMID: 35031483
DOI: 10.1016/j.nbd.2022.105622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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