Article
Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development.
Ophthalmology - 1 Jun 2022
Simcoe Mark J, Shah Ameet, Fan Baojian, Choquet Hélène, Weisschuh Nicole, Waseem Naushin H, Jiang Chen, Melles Ronald B, Ritch Robert, Mahroo Omar A, Wissinger Bernd, Jorgenson Eric, Wiggs Janey L, Garway-Heath David F, Hysi Pirro G, Hammond Christopher J
Abstract excerpt
PURPOSE: To identify genetic variants associated with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in unrelated patients and to further understand the genetic and potentially causal relationships between PDS and associated risk factors. DESIGN: A 2-stage genome-wide association meta-analysis with replication and subsequent in silico analyses including Mendelian randomization. PARTICIPANTS: A...
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