Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.

doi:10.1038/s41586-021-04387-1

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Article

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.

Nature - 1 Feb 2022

Cele Sandile, Jackson Laurelle, Khoury David S, Khan Khadija, Moyo-Gwete Thandeka, Tegally Houriiyah, San James Emmanuel, Cromer Deborah, Scheepers Cathrine, Amoako Daniel G, Karim Farina, Bernstein Mallory, Lustig Gila, Archary Derseree, Smith Muneerah, Ganga Yashica, Jule Zesuliwe, Reedoy Kajal, Hwa Shi-Hsia, Giandhari Jennifer, Blackburn Jonathan M, Gosnell Bernadett I, Abdool Karim Salim S, Hanekom Willem, von Gottberg Anne, Bhiman Jinal N, Lessells Richard J, Moosa Mahomed-Yunus S, Davenport Miles P, de Oliveira Tulio, Moore Penny L, Sigal Alex

Abstract excerpt

The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were...

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Identifiers

PMID: 35016196
DOI: 10.1038/s41586-021-04387-1
PMCID: PMC8866126

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