Article
The QseEF Two-Component System-GlmY Small RNA Regulatory Pathway Controls Swarming in Uropathogenic Proteus mirabilis.
International journal of molecular sciences - 1 Jan 2022
Lin Wen-Yuan, Lee Yuan-Ju, Yu Ping-Hung, Tsai Yi-Lin, She Pin-Yi, Li Tzung-Shian, Liaw Shwu-Jen
Abstract excerpt
Bacterial sensing of environmental signals through the two-component system (TCS) plays a key role in modulating virulence. In the search for the host hormone-sensing TCS, we identified a conserved qseEGF locus following glmY, a small RNA (sRNA) gene in uropathogenic Proteus mirabilis. Genes of glmY-qseE-qseG-qseF constitute an operon, and QseF binding sites were found in the glmY promoter region. Deletion of...
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