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RNA and protein expression analysis of HLA-DQB103:01:01:21Q allele: A null allele renamed as HLA-DQB103:01:01:21N.

HLA - 1 Mar 2022

Marin Rubio Luis Alberto, Aroca-Aguilar Jose Daniel, Luis-Hidalgo Mar, Escribano Julio, Ontañon Jesus

Abstract excerpt

The characterization of the expression profile of HLA questionable alleles (Q) is clinically relevant in allogeneic hematopoietic stem cell transplantation (HSTC) because an aberrant expression of these alleles could lead to transplantation-related complications. HLA-DQB1*03:01:01:21Q shows a substitution at the donor splice site of intron 3 that potentially could affect the expression of this allele. In order to...

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PMID: 34997833
DOI: 10.1111/tan.14537

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