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Article

Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights.

Journal of cellular and molecular medicine - 1 Feb 2022

Panteli Michalis, Vun James S H, Pountos Ippokratis, J Howard Anthony, Jones Elena, Giannoudis Peter V

Abstract excerpt

Fracture non-union represents a common complication, seen in 5%-10% of all acute fractures. Despite the enhancement in scientific understanding and treatment methods, rates of fracture non-union remain largely unchanged over the years. This systematic review investigates the biological, molecular and genetic profiles of both (i) non-union tissue and (ii) non-union-related tissues, and the genetic predisposition...

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Identifiers

PMID: 34984803
DOI: 10.1111/jcmm.17096
PMCID: PMC8817135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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