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Research on a rat model of genotype IV swine hepatitis E virus.

Veterinary medicine and science - 1 Mar 2022

Jian Zhijie, Li Youyou, Xu Zhiwen, Zhao Jun, Li Fengqin, Deng Huidan, Sun Xiangang, Zhu Ling

Abstract excerpt

BACKGROUND: Hepatitis E virus (HEV) is an important zoonotic pathogen, Genotypes 3 and 4 are the main zoonotic genotype. Due to the lack of mature and effective culture cell lines, researches on genotype IV swine HEV (SHEV-4) infection and pathogenic mechanism have been carried out in pigs, gerbils and non-human primate models. OBJECTIVES: The aim of this study was to establish a rat infection model by...

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Identifiers

PMID: 34981892
DOI: 10.1002/vms3.707
PMCID: PMC8959259

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