Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 1 Jan 2022

Yamazawa Toshiko, Kobayashi Takuya, Kurebayashi Nagomi, Murayama Takashi

Abstract excerpt

Type 1 ryanodine receptor (RyR1) plays a key role in Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling of skeletal muscle. Mutations in RyR1 hyperactivate the channel to cause malignant hyperthermia (MH). MH is a serious complication characterized by skeletal muscle rigidity and elevated body temperature in response to commonly used inhalational anesthetics. Thus far, more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Malignant Hyperthermia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Mutation

Share to Ryanodine Receptor Calcium Release Channel

Share to Sarcoplasmic Reticulum

Source

Identifiers

PMID: 34980804
DOI: 10.1254/fpj.21068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases].PMID 34980804Read ↗

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat strokeSemantic proximity Read ↗

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.Semantic proximity Read ↗

Beneficial Effects of Dantrolene in the Treatment of Rhabdomyolysis as a Potential Late Complication Associated With COVID-19: A Case ReportSemantic proximity Read ↗

Drug development for the treatment of RyR1-related skeletal muscle diseases.Semantic proximity Read ↗

Pharmacokinetics of Dantrolene in the CVVH/PE Treatment of Malignant Hyperthermia in a 14-year-old Chinese Boy: A Case Report and Literature ReviewSemantic proximity Read ↗

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantroleneSemantic proximity Read ↗

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.Semantic proximity Read ↗

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantroleneSemantic proximity Read ↗

Hypothesis: exertional heat stroke-induced myopathy and genetically inherited malignant hyperthermia represent the same disorder, the human stress syndrome.Semantic proximity Read ↗

Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene.Semantic proximity Read ↗

The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia.Semantic proximity Read ↗

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.