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Article

No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients.

Journal of pineal research - 1 Mar 2022

Xue Pei, Tan Xiao, Wu Jiafei, Tang Xiangdong, Benedict Christian

Abstract excerpt

The minor G risk allele in the common melatonin receptor gene (MTNR1B, rs10830963) has been associated with an increased risk of myocardial infarction among patients with type 2 diabetes (T2D). Furthermore, activating the melatonin receptor 1B through melatonin has been shown to promote cell proliferation, which could be hypothesized to increase cancer risk. Cardiovascular disease (CVD) and cancer are common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34967052
DOI: 10.1111/jpi.12785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech WomenSemantic proximity Read ↗

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.Semantic proximity Read ↗

Association between a functional polymorphism rs10830963 in <i>melatonin receptor 1B</i> and risk of gestational diabetes mellitus: an updated meta-analysisSemantic proximity Read ↗

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A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus.Semantic proximity Read ↗

Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.Semantic proximity Read ↗

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The association between melatonin receptor 1B gene polymorphisms and type 2 diabetes mellitus (T2DM) in Chinese populations: a meta-analysis.Semantic proximity Read ↗

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