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Article

Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes

1 Dec 2021

Abstract excerpt

Enteric pathogens overcome barrier immunity within the intestinal environment that includes the endogenous flora. The microbiota produces diverse ligands, and the full spectrum of microbial products that are sensed by the epithelium and prime protective immunity is unknown. Using Drosophila, we find that the gut presents a high barrier to infection, which is partially due to signals from the microbiota, as loss...

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PMID: 34965418
DOI: 10.1016/j.celrep.2021.110150

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