Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk.

doi:10.1002/jbmr.4494

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2022

Whittier Danielle E, Samelson Elizabeth J, Hannan Marian T, Burt Lauren A, Hanley David A, Biver Emmanuel, Szulc Pawel, Sornay-Rendu Elisabeth, Merle Blandine, Chapurlat Roland, Lespessailles Eric, Wong Andy Kin On, Goltzman David, Khosla Sundeep, Ferrari Serge, Bouxsein Mary L, Kiel Douglas P, Boyd Steven K

Abstract excerpt

Prevalence of osteoporosis is more than 50% in older adults, yet current clinical methods for diagnosis that rely on areal bone mineral density (aBMD) fail to detect most individuals who have a fragility fracture. Bone fragility can manifest in different forms, and a "one-size-fits-all" approach to diagnosis and management of osteoporosis may not be suitable. High-resolution peripheral quantitative computed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Absorptiometry, Photon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged

Share to Bone and Bones

Share to Bone Density

Share to Bone health and osteoporosis research

Share to Osteoporosis

Share to Osteoporotic Fractures

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 34953074
DOI: 10.1002/jbmr.4494
PMCID: PMC9249128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk.PMID 34953074Read ↗

Hip Fractures in Older Adults Are Associated With the Low Density Bone Phenotype and Heterogeneous Deterioration of Bone Microarchitecture.Semantic proximity Read ↗

Cluster analysis of bone microarchitecture from high resolution peripheral quantitative computed tomography demonstrates two separate phenotypes associated with high fracture risk in men and women.Semantic proximity Read ↗

Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical ImagingSemantic proximity Read ↗

Choose your mother wisely: the familial resemblance of bone adaptation.Semantic proximity Read ↗

Genetic Determinants of Bone Microarchitecture and its Association with Health Outcomes: A Genome-wide Association and Mendelian Randomization Study on Trabecular Bone ScoreSemantic proximity Read ↗

Age-, Site-, and Sex-Specific Normative Centile Curves for HR-pQCT-Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland PopulationSemantic proximity Read ↗

Deep Learning Using High-Resolution Images of Forearm Predicts FractureSemantic proximity Read ↗

Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis riskSemantic proximity Read ↗

Transferability of bone phenotyping and fracture risk assessment by μFRAC from first-generation high-resolution peripheral quantitative computed tomography to second-generation scan data.Semantic proximity Read ↗

Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Semantic proximity Read ↗

Prediction of Bone Mineral Density and Fragility Fracture by Genetic ProfilingSemantic proximity Read ↗

The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.