Article
Archiving of mutations in HIV-1 cellular reservoirs among vertically infected adolescents is contingent with clinical stages and plasma viral load: Evidence from the EDCTP-READY study.
HIV medicine - 1 Jul 2022
Fokam Joseph, Mpouel Bala Marie Laure, Santoro Maria-Mercedes, Takou Désiré, Tala Valère, Beloumou Grace, Ngoufack Ezechiel Semengue, Chenwi Collins, Pabo Willy Leroi Togna, Njume Debimeh, Teto Georges, Dambaya Beatrice, Djupsa Sandrine, Sosso Samuel, Ateba Francis, Kamta Cedric, Bala Lionel, Njom Nlend Anne-Esther, Koki Ndombo Paul, Colizzi Vittorio, Perno Carlo Frederico, Ndjolo Alexis
Abstract excerpt
INTRODUCTION: Globally, HIV-related adolescent deaths have increased about 50%, especially for those who are vertically infected. This could be driven by archived drug resistance mutations (DRMs) as children grow up, which might jeopardize antiretroviral therapy (ART). Our objective was to compare HIV-1 genotypic variation between plasma RNA and proviral DNA of vertically infected adolescents (aged 10-19 years)...
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