Article
Positive Association Between Location of Melanoma, Ultraviolet Signature, Tumor Mutational Burden, and Response to Anti-PD-1 Therapy.
JCO precision oncology - 1 Jan 2021
Dousset Léa, Poizeau Florence, Robert Caroline, Mansard Sandrine, Mortier Laurent, Caumont Charline, Routier Émilie, Dupuy Alain, Rouanet Jacques, Battistella Maxime, Greliak Anna, Cappellen David, Galibert Marie-Dominique, Allayous Clara, Lespagnol Alexandra, Gerard Émilie, Kerneuzet Inès, Roy Séverine, Dutriaux Caroline, Merlio Jean-Philippe, Vergier Beatrice, Schrock Alexa B, Lee Jessica, Ali Siraj M, Kammerer-Jacquet Solène-Florence, Lebbé Céleste, Beylot-Barry Marie, Boussemart Lise
Abstract excerpt
Emerging evidence suggests a correlation between the tumor mutational burden (TMB) and the response to programmed cell death-1 protein (PD-1) monotherapy across multiple cancer types. In skin cancers, as high TMB is mostly because of ultraviolet (UV) exposure, we hypothesized a correlation between the primary melanoma cutaneous location according to sun exposure and response to anti-PD-1 monotherapy. METHODS: The...
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