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Article

Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis.

International journal of molecular sciences - 16 May 2022

Hung Pei-Fang, Chung Fa-Po, Hung Chung-Lieh, Lin Yenn-Jiang, Kuo Tzu-Ting, Liao Jo-Nan, Chen Yun-Yu, Pan Chih-Hsin, Shaw Kai-Ping, Chen Shih-Ann

Abstract excerpt

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted to identify potential targets by immunohistochemical (IHC) analysis in comparison with controls. Pathogenic mutations were identified in 11 of 37...

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Identifiers

PMID: 35628349
DOI: 10.3390/ijms23105529
PMCID: PMC9141850

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