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Article

Dog models of naturally occurring cancer.

Trends in molecular medicine - 1 Jul 2011

Rowell Jennie L, McCarthy Donna O, Alvarez Carlos E

Abstract excerpt

Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies...

Topics

Animals
Bone Neoplasms
Breeding
Disease Models, Animal
Dogs
Genetic Variation
Genome
Humans
Lymphoma
Osteosarcoma
Sarcoma
Translational Research, Biomedical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21439907
DOI: 10.1016/j.molmed.2011.02.004
PMCID: PMC3130881

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