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Reduction of blood group A antigen on erythrocytes in a patient with myelodysplastic syndrome harboring somatic mutations in RUNX1 and GATA2.

Transfusion - 1 Feb 2022

Hayakawa Akira, Sano Rie, Takahashi Yoichiro, Okawa Takafumi, Kubo Rieko, Harada Megumi, Fukuda Haruki, Yokohama Akihiko, Handa Hiroshi, Kawabata-Iwakawa Reika, Tsuneyama Hatsue, Tsukada Junichi, Kominato Yoshihiko

Abstract excerpt

BACKGROUND: Reduction of blood group ABO antigens on red blood cells (RBCs) is well known in patients with leukemias, and this reduction of ABO expression is strongly associated with DNA methylation of the ABO promoter. Previously, we reported a two-nucleotide deletion in RUNX1 encoding an abnormally elongated protein lacking the trans-activation domain in a patient with myelodysplastic syndrome (MDS) showing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34918362
DOI: 10.1111/trf.16766

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Reduction of blood group A antigen on erythrocytes in a patient with myelodysplastic syndrome harboring somatic mutations in RUNX1 and GATA2.PMID 34918362Read ↗

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