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Article

Origins of biallelic inactivation of NF2 in neurofibromatosis type 2.

Neuro-oncology - 1 Jun 2022

Xue Lu, He Weiwei, Zhang Yi, Wang Zhigang, Chen Hongsai, Chen Zhe, Zhu Weidong, Liu Dongmei, Jia Huan, Jiang Yi, Wang Zhaoyan, Wu Hao

Abstract excerpt

BACKGROUND: Elucidating the mechanism by which biallelic inactivation evolved could provide a mechanistic understanding for NF2 tumorigenesis and also a rationale for clinical management. METHODS: A cohort of 60 NF2 patients was recruited. Next-generation sequencing of tumor and paired control samples was used to explore how NF2 mutations evolve in determining the clinical phenotypes. RESULTS: In total, 60 blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34918118
DOI: 10.1093/neuonc/noab287
PMCID: PMC9159453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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