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Article

A20 Haploinsufficiency in East Asia.

Frontiers in immunology - 1 Jan 2021

Kadowaki Tomonori, Kadowaki Saori, Ohnishi Hidenori

Abstract excerpt

A20, encoded by the TNFAIP3 gene, is a negative regulator of tumor necrosis factor (TNF)-nuclear factor-κB signaling. It was recently demonstrated that A20 haploinsufficiency (HA20), caused by a heterozygous mutation in the TNFAIP3 gene, can present as an early onset autoinflammatory disease resembling Behçet's disease (BD). In addition to autoinflammatory symptoms, HA20 was also reported to be associated with...

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Identifiers

PMID: 34899744
DOI: 10.3389/fimmu.2021.780689
PMCID: PMC8664410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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