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Article

A20 Haploinsufficiency in East Asia.

Frontiers in immunology - 1 Jan 2021

Kadowaki Tomonori, Kadowaki Saori, Ohnishi Hidenori

Abstract excerpt

A20, encoded by the TNFAIP3 gene, is a negative regulator of tumor necrosis factor (TNF)-nuclear factor-κB signaling. It was recently demonstrated that A20 haploinsufficiency (HA20), caused by a heterozygous mutation in the TNFAIP3 gene, can present as an early onset autoinflammatory disease resembling Behçet's disease (BD). In addition to autoinflammatory symptoms, HA20 was also reported to be associated with...

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Asia, Eastern
Autoimmune Diseases
Genetic Predisposition to Disease
Haploinsufficiency
Hereditary Autoinflammatory Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Necrosis Factor alpha-Induced Protein 3

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Identifiers

PMID: 34899744
DOI: 10.3389/fimmu.2021.780689
PMCID: PMC8664410

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