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Article

Association of Clinical Phenotypes in Haploinsufficiency A20 (HA20) With Disrupted Domains of A20.

Frontiers in immunology - 1 Jan 2020

Chen Yu, Ye Zhenghao, Chen Liping, Qin Tingting, Seidler Ursula, Tian De'an, Xiao Fang

Abstract excerpt

Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. This study aims at exploring the association between the various manifestations of HA20 and...

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Identifiers

PMID: 33101300
DOI: 10.3389/fimmu.2020.574992
PMCID: PMC7546856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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