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Article

A convenient test system for the identification of CYP4V2 inhibitors.

Molecular vision - 1 Jan 2021

Sharma Shishir, Liu Sijie, Durairaj Pradeepraj, Machalz David, Wolber Gerhard, Bureik Matthias

Abstract excerpt

Purpose: Polymorphisms in the gene that codes for the human cytochrome P450 enzyme CYP4V2 are a cause of Bietti crystalline dystrophy (BCD). Therefore, inhibition of CYP4V2 activity may well be a cause of visual disability. However, monitoring the fatty acid hydroxylation reactions catalyzed by this enzyme is tedious and not well suited for inhibitor screening. Methods: We investigated the use of proluciferin...

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Identifiers

PMID: 34880593
PMCID: PMC8598247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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