Article
Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants.
Glycobiology - 26 Feb 2022
Kuo Chu-Wei, Yang Tzu-Jing, Chien Yu-Chun, Yu Pei-Yu, Hsu Shang-Te Danny, Khoo Kay-Hooi
Abstract excerpt
Extensive glycosylation of the spike protein of severe acute respiratory syndrome coronavirus 2 virus not only shields the major part of it from host immune responses, but glycans at specific sites also act on its conformation dynamics and contribute to efficient host receptor binding, and hence infectivity. As variants of concern arise during the course of the coronavirus disease of 2019 pandemic, it is unclear...
Topics
Join the communities discussing this publication.
