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Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer

1 Oct 2021

Abstract excerpt

OBJECTIVES: The potential of DNA methylation alterations in early pancreatic cancer (PC) detection among pancreatic tissue cell-free DNA seems promising. This study investigates the diagnostic capacity of the 4-gene methylation biomarker panel, which included ADAMTS1, BNC1, LRFN5, and PXDN genes, in a case-control study. METHODS: A genome-wide pharmacoepigenetic approach identified ADAMTS1, BNC1, LRFN5, and PXDN...

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PMID: 34860810
DOI: 10.1097/mpa.0000000000001919

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