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Article

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants.

Nature communications - 30 Nov 2021

Koehler Melanie, Ray Ankita, Moreira Rodrigo A, Juniku Blinera, Poma Adolfo B, Alsteens David

Abstract excerpt

Despite an unprecedented global gain in knowledge since the emergence of SARS-CoV-2, almost all mechanistic knowledge related to the molecular and cellular details of viral replication, pathology and virulence has been generated using early prototypic isolates of SARS-CoV-2. Here, using atomic force microscopy and molecular dynamics, we investigated how these mutations quantitatively affected the kinetic,...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Atomic Force

Share to Molecular Dynamics Simulation

Share to Protein Interaction Domains and Motifs

Share to Protein Stability

Share to Spike Glycoprotein, Coronavirus

Share to Thermodynamics

Source

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Identifiers

PMID: 34848718
DOI: 10.1038/s41467-021-27325-1
PMCID: PMC8633007

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