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Production of Hydroxycarboxylic Acid Receptor 3 (HCA3) Ligands by Bifidobacterium

21 Nov 2021

Abstract excerpt

Hydroxycarboxylic acid receptor 3 (HCA3) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA3 ligands by Bifidobacterium spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by Bifidobacterium as an HCA3 ligand. The four ligands produced were the mixtures...

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PMID: 34835522
DOI: 10.3390/microorganisms9112397

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