Article
MR imaging for the quantitative assessment of brain iron in aceruloplasminemia: A postmortem validation study.
NeuroImage - 15 Dec 2021
Vroegindeweij Lena H P, Wielopolski Piotr A, Boon Agnita J W, Wilson J H Paul, Verdijk Rob M, Zheng Sipeng, Bonnet Sylvestre, Bossoni Lucia, van der Weerd Louise, Hernandez-Tamames Juan A, Langendonk Janneke G
Abstract excerpt
AIMS: Non-invasive measures of brain iron content would be of great benefit in neurodegeneration with brain iron accumulation (NBIA) to serve as a biomarker for disease progression and evaluation of iron chelation therapy. Although magnetic resonance imaging (MRI) provides several quantitative measures of brain iron content, none of these have been validated for patients with a severely increased cerebral iron...
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