MiR-27a-5p inhibits malignant progression of differentiated thyroid cancer through SREBP1 and is associated with thyrotropin suppressive therapy

Abstract excerpt

<title>Abstract</title> <p>Purpose To detect the expression of miR-27a-5p in differentiated thyroid cancer (DTC) and to explore its correlation with SREBP1 expression, DTC malignant progression, and TSH suppression therapy. Methods The expression levels of SREBP1 and miR-27a-5p in DTC tissues (n = 75) were detected by qRT-PCR. The expression of miR-27a-5p and SREBP1 was statistically analyzed for correlation wi...

Topics

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• Apoptosis
• Cell Movement
• Cell Proliferation
• Gene Expression Regulation, Neoplastic
• MicroRNAs
• Phenotype
• Receptors, LDL
• Thyroid Neoplasms

Identifiers and source

Literature Corpus work

67292139-d1cc-5418-930b-832542af7389

DOI

10.21203/rs.3.rs-4819650/v1