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Article

MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection.

Scientific reports - 22 Nov 2021

Verceles Avelino C, Bhat Pavan, Nagaria Zain, Martin Destiny, Patel Harsh, Ntem-Mensah Afua, Hyun Sang W, Hahn Andrea, Jeudy Jean, Cross Alan S, Lillehoj Erik P, Goldblum Simeon E

Abstract excerpt

We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo. Here, we asked whether Pa in the lungs of patients with ventilator-associated pneumonia might also increase MUC1-ED shedding. The levels of MUC1-ED and Pa-expressed flagellin were dramatically elevated in...

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Identifiers

PMID: 34811449
DOI: 10.1038/s41598-021-02242-x
PMCID: PMC8608881

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