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Clonal hematopoiesis and VEXAS syndrome: survival of the fittest clones?

Seminars in hematology - 1 Oct 2021

Kusne Yael, Fernandez Jenna, Patnaik Mrinal M

Abstract excerpt

Clonal hematopoiesis (CH) is defined by the acquisition of somatic mutations in hematopoietic stem cells (HSC) leading to enhanced cellular fitness and proliferation under positive clonal selection pressures. CH most frequently involves epigenetic regulator genes (DNMT3A, TET2 and ASXL1), with these mutations being associated with enhanced inflammation and increased all-cause mortality largely from cardiovascular...

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Identifiers

PMID: 34802544
DOI: 10.1053/j.seminhematol.2021.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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